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. 1979 Apr;42(4):380-3.
doi: 10.1136/jnnp.42.4.380.

Tiapride in levodopa-induced involuntary movements

A J Lees, C M Lander, G M Stern

Tiapride in levodopa-induced involuntary movements

A J Lees et al. J Neurol Neurosurg Psychiatry. 1979 Apr.

Abstract

Tiapride, a substituted benzamide derivative closely related to metoclopramide, reduced levodopa-induced peak dose involuntary movements in 16 patients with idiopathic Parkinson's disease. However, an unacceptable increase in disability from Parkinsonism with aggravation of end-of-dose akinesia led to its cessation in 14 patients. Tiapride had no effect on levodopa-induced early morning of "off-period" segmental dystonia. These results fail to support the notion that levodopa-induced dyskinesias are caused by overstimulation of a separate group of dopamine receptors.

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References

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