doi: 10.1007/BF01059445.
A linear recirculation model for drug disposition
- PMID: 458553
- DOI: 10.1007/BF01059445
Item in Clipboard
A linear recirculation model for drug disposition
J Pharmacokinet Biopharm.
1979 Feb.
Abstract
A new approach to the modeling of drug disposition is described. Disposition is regarded as the result of repetitive passes of the drug around the circulation. Mathematical analysis of experimental blood concentration data yields an expression describing the kinetics of a single pass through the tissues. In physicochemical terms the single-pass behavior depends to a large extent on the interaction of the drug with individual tissues, which greatly simplifies interpretation. The method may reveal features of disposition not apparent from experimental blood concentration data.
Similar articles
-
Theorems and implications of a model independent elimination/distribution function decomposition of linear and some nonlinear drug dispositions. I. Derivations and theoretical analysis.J Pharmacokinet Biopharm. 1984 Dec;12(6):627-48. doi: 10.1007/BF01059557. J Pharmacokinet Biopharm. 1984. PMID: 6533297
-
Properties of the recirculation model: matrix description and conditions for a monotonic decreasing single pass response.J Pharmacokinet Biopharm. 1981 Apr;9(2):217-23. doi: 10.1007/BF01068083. J Pharmacokinet Biopharm. 1981. PMID: 7277210
-
Theorems and implications of a model-independent elimination/distribution function decomposition of linear and some nonlinear drug dispositions. II. Clearance concepts applied to the evaluation of distribution kinetics.J Pharmacokinet Biopharm. 1985 Aug;13(4):441-51. doi: 10.1007/BF01061479. J Pharmacokinet Biopharm. 1985. PMID: 4087171
-
Integrated pharmacokinetic-dynamic modeling of drugs acting on the CNS.Drug Metab Rev. 1984;15(1-2):383-400. doi: 10.3109/03602538409015073. Drug Metab Rev. 1984. PMID: 6378561 Review.
-
Pharmacokinetics of drug disposition: hemodynamic considerations.Annu Rev Pharmacol. 1975;15:11-27. doi: 10.1146/annurev.pa.15.040175.000303. Annu Rev Pharmacol. 1975. PMID: 1096786 Review. No abstract available.
Cited by
-
Pharmacokinetic stochastic model with Weibull-distributed residence times of drug molecules in the body.Eur J Clin Pharmacol. 1987;32(5):515-23. doi: 10.1007/BF00637680. Eur J Clin Pharmacol. 1987. PMID: 2441996
-
Theorems and implications of a model independent elimination/distribution function decomposition of linear and some nonlinear drug dispositions. I. Derivations and theoretical analysis.J Pharmacokinet Biopharm. 1984 Dec;12(6):627-48. doi: 10.1007/BF01059557. J Pharmacokinet Biopharm. 1984. PMID: 6533297
-
Pharmacokinetics from a dynamical systems point of view.J Pharmacokinet Biopharm. 1989 Jun;17(3):365-92; discussion 393-400. doi: 10.1007/BF01061902. J Pharmacokinet Biopharm. 1989. PMID: 2486192
-
Modelling of initial distribution of drugs following intravenous bolus injection.Eur J Clin Pharmacol. 1983;24(1):121-6. doi: 10.1007/BF00613938. Eur J Clin Pharmacol. 1983. PMID: 6832194
-
Properties of the recirculation model: calculation of the amount of drug in the body from blood concentration data, with application to absorption rate calculations.J Pharmacokinet Biopharm. 1981 Apr;9(2):225-34. doi: 10.1007/BF01068084. J Pharmacokinet Biopharm. 1981. PMID: 7277211