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. 1979 Jul;68(7):880-2.
doi: 10.1002/jps.2600680725.

High-performance liquid chromatographic assay for the anthelmintic agent mebendazole in human plasma

K B Alton, J E Patrick, J L McGuire

High-performance liquid chromatographic assay for the anthelmintic agent mebendazole in human plasma

K B Alton et al. J Pharm Sci. 1979 Jul.

Abstract

A rapid and specific high-performance liquid chromatographic (HPLC) assay for quantitative plasma mebendazole determination is described. After a simple extraction, the compound was analyzed by HPLC using a reversed-phase column and a UV detector (313 nm). Quantitation was accomplished using an internal standard; peak area ratios were determined with an integrating computer. The average mebendazole recovery over a concentration range of 0.01-0.20 microgram/ml was 75.9 +/- 3.8% SD, and the maximum assay sensitivity was approximately 10 ng/ml.

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