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. 1973 Sep;4(3):316-9.
doi: 10.1128/AAC.4.3.316.

Selective membrane toxicity of the polyene antibiotics: studies on natural membranes

C C Hsuchen, D S Feingold

Selective membrane toxicity of the polyene antibiotics: studies on natural membranes

C C Hsuchen et al. Antimicrob Agents Chemother. 1973 Sep.

Abstract

The effect of polyene antibiotics on Candida albicans, human erythrocytes, and Acholeplasma laidlawii was studied. The results sustain the observations made with lecithin-sterol liposomes. The distribution of double bonds in the membrane sterol nucleus appears to be of major importance in conferring polyene susceptibility; those sterols with the ergosterol nucleus are far more effective than those with a nucleus similar to cholesterol. Different polyenes vary in their membrane selectivity. The clinical implications of these observations are discussed.

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