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. 1973 Dec;70(12):3581-4.
doi: 10.1073/pnas.70.12.3581.

The nucleotide sequence of the lac operator

W Gilbert, A Maxam

The nucleotide sequence of the lac operator

W Gilbert et al. Proc Natl Acad Sci U S A. 1973 Dec.

Abstract

The lac repressor protects the lac operator against digestion with deoxyribonuclease. The protected fragment is double-stranded and about 27 base-pairs long. We determined the sequence of RNA transcription copies of this fragment and present a sequence for 24 base pairs. It is: 5'--T G G A A T T G T G A G C G G A T A A C A A T T 3' 3'--A C C T T A A C A C T C G C C T A T T G T T A A 5' The sequence has 2-fold symmetry regions; the two longest are separated by one turn of the DNA double helix.

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References

    1. Nature. 1967 Apr 15;214(5085):232-4 - PubMed
    1. J Mol Biol. 1971 Nov 28;62(1):139-69 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3585-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3576-80 - PubMed
    1. J Mol Biol. 1961 Jun;3:318-56 - PubMed

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