Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Jan;117(1):56-62.
doi: 10.1128/jb.117.1.56-62.1974.

Molecular specificities of R factor-determined beta-lactamases: correlation with plasmid compatibility

R W Hedges, N Datta, P Kontomichalou, J T Smith

Molecular specificities of R factor-determined beta-lactamases: correlation with plasmid compatibility

R W Hedges et al. J Bacteriol. 1974 Jan.

Abstract

Beta (beta)-lactamases determined by 29 ampicillin resistance plasmids could be divided into two types. One, TEM-type, was very uniform with respect to substrate specificity but heterogeneous in absolute levels of beta-lactamase activity. The TEM-type beta-lactamase was determined by R factors of compatibility groups FII, Ialpha, Iepsilon, N, C, A, T, W, P, L, and X, and by prophage phi Amp. The other type, characterized by the ability to hydrolyze oxacillin, was less common, showed lower absolute levels of activity, and was heterogeneous as regards substrate specificities. Oxacillin-hydrolyzing beta-lactamases were determined by R factors of compatibility groups FI, Ialpha, N, C, and O.

PubMed Disclaimer

References

    1. J Bacteriol. 1971 Dec;108(3):1244-9 - PubMed
    1. Biochem J. 1971 Jul;123(4):507-12 - PubMed
    1. Nat New Biol. 1972 Aug 16;238(85):205-6 - PubMed
    1. Biochem J. 1972 Jun;128(1):173-4 - PubMed
    1. J Bacteriol. 1972 Nov;112(2):666-75 - PubMed

LinkOut - more resources