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. 1979 May;22(5):586-8.
doi: 10.1021/jm00191a026.

Synthesis of a proposed thymic factor

R G Strachan, W J Paleveda Jr, S J Bergstrand, R F Nutt, F W Holly, D F Veber

Synthesis of a proposed thymic factor

R G Strachan et al. J Med Chem. 1979 May.

Abstract

Less than Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn, a proposed serum thymic factor, has been synthesized. The protected precursor, less than Glu-Ala-Lys(i-Noc)-ser(Bzl)-Gln-Gly-Gly-Ser(Bzl)-Asn, was prepared by a combination of solid phase and solution methods. The benzyl blocking groups were removed by HF and the i-Noc blocking group was removed by catalytic hydrogenation.

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