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. 1979 May;22(5):599-601.
doi: 10.1021/jm00191a031.

1-(Dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinol esters. New potent antiamebic agents

D M Bailey, E M Mount, J Siggins, J A Carlson, A Yarinsky, R G Slighter

1-(Dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinol esters. New potent antiamebic agents

D M Bailey et al. J Med Chem. 1979 May.

Abstract

A series of 1-(dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinols and certain O-acyl derivatives thereof have been prepared and shown to be potent antiamebic agents in the Entamoeba criceti infected hamster model. Compounds were compared with etichlordifene and diloxamide and one of them, 1-(dichloroacetyl)-6-(2-furoyloxy)-1,2,3,4-tetrahydroquinoline (4), was selected for human trial.

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