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. 1979 Jun 8;13(1):85-93.
doi: 10.1007/BF01732756.

On the analysis of unrestricted mixed cultures in determining the fitness of microbial mutants

On the analysis of unrestricted mixed cultures in determining the fitness of microbial mutants

R T Vinopal. J Mol Evol. .

Abstract

Equations describing the growth of two microbial strains in unrestricted mixed culture are developed and their use described. With this treatment, mixed cultures maintained in growth by periodic dilution or by use of a turbidostat may be used to obtain a quantitative measure of the adaptive or maladaptive effects of specific mutant alleles.

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