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. 1972 Jul;111(1):7-14.
doi: 10.1128/jb.111.1.7-14.1972.

Loss of R factors promoted by bacteriophage M13 and the M13 carrier state

S E Russell, V N Iyer

Loss of R factors promoted by bacteriophage M13 and the M13 carrier state

S E Russell et al. J Bacteriol. 1972 Jul.

Abstract

The infection of different Hfr strains of Escherichia coli bearing derepressed R factors of the fi(+) or fi(-) type can result in the loss of the R factor and the conversion of the infected cells to the R(-) state. This extends earlier observations on the elimination of F' factors by bacteriophage M13 infection. Variability in the efficiency of this conversion can arise because of genetic factors independent of the R factor being eliminated. A fraction of the infected but unconverted R(+) cells were M13 carrier strains. The carrier state had an intracellular basis, and single R(+) cells could maintain the carrier state.

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