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. 1974 Mar;117(3):1240-7.
doi: 10.1128/jb.117.3.1240-1247.1974.

Oxaluric acid: a non-metabolizable inducer of the allantoin degradative enzymes in Saccharomyces cerevisiae

R Sumrada, T G Cooper

Oxaluric acid: a non-metabolizable inducer of the allantoin degradative enzymes in Saccharomyces cerevisiae

R Sumrada et al. J Bacteriol. 1974 Mar.

Abstract

Saccharomyces cerevisiae degrades allantoin in five steps to ammonia, CO(2), and glyoxylate. Previously we demonstrated that allophanic acid, the last intermediate of the pathway, was required for induction of all five degradative enzymes. The data presented here indicate that oxaluric acid, an allophanate analogue, is capable of serving as a non-metabolizable inducer. Oxaluric acid brings about a high level of induction even in strains lacking urea carboxylase. Induction observed with parabanic acid was found to result from its spontaneous breakdown to oxaluric acid.

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References

    1. Proc Natl Acad Sci U S A. 1971 Jan;68(1):215-8 - PubMed
    1. Arch Biochem Biophys. 1955 Jun;56(2):405-11 - PubMed
    1. J Biol Chem. 1972 Mar 10;247(5):1349-53 - PubMed
    1. Biochem Biophys Res Commun. 1973 May 1;52(1):137-42 - PubMed
    1. J Biol Chem. 1973 Sep 10;248(17):6203-9 - PubMed

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