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. 1979 Apr 17;57(8):417-9.
doi: 10.1007/BF01480481.

Activation of human large bowel adenylate cyclase by methylated prostaglandin E2 analogues

B Simon, K R Koczorek, H Kather

Activation of human large bowel adenylate cyclase by methylated prostaglandin E2 analogues

B Simon et al. Klin Wochenschr. .

Abstract

The effects of methylated analogues of prostaglandin E2 upon the adenylate cyclase system in human colonic mucosa were tested. 16,16-dimethyl-prostaglandin E2 and 15-(S)-methyl-prostaglandin E2 increased the cyclase system in a dose-related manner. Maximal stimulation (about 250%) of enzyme activity occurred at a prostaglandin analogue concentration of 0.1 g/l. Diarrhea seen in patients treated with these orally effective prostaglandin analogues might in part be explained by activation of large bowel adenylate cyclase which is supposed to play a key role in the secretory process in this organ.

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