doi: 10.1126/science.184.4135.482.
Somatostatin: hypothalamic inhibitor of the endocrine pancreas
- PMID: 4594711
- DOI: 10.1126/science.184.4135.482
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Somatostatin: hypothalamic inhibitor of the endocrine pancreas
Science.
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Abstract
Somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone, inhibits basal insulin secretion in fasted cats and rats. In fasted baboons both basal and arginine-stimulated secretion of insulin and glucagon are inhibited. Somatostatin appears to act directly on the endocrine pancreas. The action is dose-related, rapid in onset, and readily reversed.
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