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. 1974 Apr 26;184(4135):482-4.
doi: 10.1126/science.184.4135.482.

Somatostatin: hypothalamic inhibitor of the endocrine pancreas

D J Koerker, W Ruch, E Chideckel, J Palmer, C J Goodner, J Ensinck, C C Gale

Somatostatin: hypothalamic inhibitor of the endocrine pancreas

D J Koerker et al. Science. .

Abstract

Somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone, inhibits basal insulin secretion in fasted cats and rats. In fasted baboons both basal and arginine-stimulated secretion of insulin and glucagon are inhibited. Somatostatin appears to act directly on the endocrine pancreas. The action is dose-related, rapid in onset, and readily reversed.

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