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. 1974 May 1;139(5):1215-27.
doi: 10.1084/jem.139.5.1215.

Activity of host-derived T cells which differentiate in nude mice grafted with co-isogenic or allogeneic thymuses

B Kindred, F Loor

Activity of host-derived T cells which differentiate in nude mice grafted with co-isogenic or allogeneic thymuses

B Kindred et al. J Exp Med. .

Abstract

If nude mice are grafted with a neonatal thymus, host type precursor cells develop within the graft thymus and after about 6 wk the T-cell population of the thymus, spleen, and lymph nodes is of host type. However, immunological responsiveness produced in nude mice in this manner is incomplete: (a) the ability to react to T-cell mitogens in vitro is greater than in untreated nudes but lower than in normal mice; (b) the response to T-cell dependent antigens is less than normal; and (c) the rejection of skin grafts is slower than in normal animals. Whether host precursor cells which differentiate in an allogeneic thymus are able to reject skin grafts from thymus donor strain appears to depend on the strain combination used.

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References

    1. Nat New Biol. 1972 Sep 27;239(91):112-4 - PubMed
    1. J Exp Med. 1970 Feb;131(2):275-86 - PubMed
    1. J Immunol. 1973 Feb;110(2):362-75 - PubMed
    1. Eur J Immunol. 1972 Jun;2(3):233-5 - PubMed
    1. Transplantation. 1965 Jan;3:28-38 - PubMed

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