Cellular requirements for the primary in vitro antibody response to DNP-ficoll
- PMID: 4596514
- PMCID: PMC2139667
- DOI: 10.1084/jem.139.5.1354
Cellular requirements for the primary in vitro antibody response to DNP-ficoll
Abstract
The cellular requirements for the primary in vitro IgM and IgG response to dinitrophenyl-substituted Ficoll were examined. Neither thymus-derived lymphocytes nor macrophage-rich splenic adherent cells were required for anti-DNP antibody synthesis. DNP-Ficoll is therefore tentatively classified as a "thymic-independent" antigen.
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