Comparison of three serological tests in gonococcal infection

Abstract

Three serological tests used in the diagnosis of gonococcal infection were compared with cultural techniques in 857 females attending the Prenatal and Gynaecology Clinics at the Winnipeg General Hospital. The tests evaluated were the microflocculation technique (MFT), the indirect fluorescent-antibody technique (IFAT), and the complement-fixation technique (CFT). One hundred six patients had positive cultures for Neisseria gonorrhoeae. In this population, the MFT was reactive in 80 patients (75.4%), the IFAT was reactive in 74 (69.8%), and the CFT was reactive in 33 (31.1%). In the 751 patients with negative cultures, the MFT was positive in 11.4%, the IFAT was positive in 17.4%, and the CFT was positive in 10.5%. Sera from 9 of 10 patients with gonococcal arthritis were positive with the MFT.