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. 1972 Sep;2(3):156-8.
doi: 10.1128/AAC.2.3.156.

Effect of ribosomal wash factors on inhibition by chloramphenicol

H J Cameron, S M Rogers, G R Julian

Effect of ribosomal wash factors on inhibition by chloramphenicol

H J Cameron et al. Antimicrob Agents Chemother. 1972 Sep.

Abstract

In vitro protein-synthesizing systems from Escherichia coli can be categorized as either chloramphenicol-sensitive or chloramphenicol-insensitive. The chloramphenicol-sensitive systems used in this study required the presence of factors removed from ribosomes with 1.0 m NH(4)Cl when chromatographically purified ribosomes were used for amino acid incorporation. These ribosomal wash factors inhibited but did not eliminate amino acid incorporation in chloramphenicol-insensitive systems. For both systems, addition of increasing amounts of the ribosomal wash factors increased the sensitivity to chloramphenicol inhibition.

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References

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