doi: 10.1128/AAC.3.2.266.
Two enzymes which phosphorylate neomycin and kanamycin in Escherichia coli strains carrying R factors
- PMID: 4597718
- PMCID: PMC444398
- DOI: 10.1128/AAC.3.2.266
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Two enzymes which phosphorylate neomycin and kanamycin in Escherichia coli strains carrying R factors
Antimicrob Agents Chemother.
1973 Feb.
Abstract
Two enzymes which phosphorylate neomycin and kanamycin have been detected in Escherichia coli strains carrying R factors. Neomycin-kanamycin phosphotransferase I can phosphorylate neomycin and kanamycin, but not butirosin. Neomycin-kanamycin phosphotransferase II can phosphorylate all three antibiotics. The enzymes also differ in their response to certain inhibitors of phosphorylation. Neomycin-kanamycin phosphotransferase II is found in certain strains of Pseudomonas aeruginosa.
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