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. 1974 Jun;118(3):1179-80.
doi: 10.1128/jb.118.3.1179-1180.1974.

Development of auxotrophy by streptomycin-resistant mutation

S L Chakrabarti, P K Maitra

Development of auxotrophy by streptomycin-resistant mutation

S L Chakrabarti et al. J Bacteriol. 1974 Jun.

Abstract

Several streptomycin-resistant mutants of Escherichia coli have been isolated which require exogenous isoleucine for growth. The majority of these strains were of streptomycin-dependent phenotype. If grown in the absence of streptomycin, these streptomycin-dependent auxotrophs (Sm(d-aux)) strains were unable to produce beta-galactosidase and aldolase activities and also failed to exhibit donor properties in conjugation. Genetic analysis indicated that the isoleucine requirement of these strains could be caused by a mutation at the strA locus.

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References

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    1. Nat New Biol. 1971 Dec 29;234(52):261-4 - PubMed
    1. Bacteriol Rev. 1970 Sep;34(3):228-77 - PubMed

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