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. 1974 Apr;71(4):1549-53.
doi: 10.1073/pnas.71.4.1549.

Isolation and function of the gene A initiator of bacteriophage phi-chi 174, a highly specific DNA endonuclease

T J Henry, R Knippers

Isolation and function of the gene A initiator of bacteriophage phi-chi 174, a highly specific DNA endonuclease

T J Henry et al. Proc Natl Acad Sci U S A. 1974 Apr.

Abstract

The gene A product of Escherichia coli bacteriophage varphiX 174, necessary for initiation of varphiX DNA synthesis, has been identified and purified to near homogeneity. The gene A protein is shown to be a highly specific DNA endonuclease which breaks one phosphodiester bond in the viral strand of either double-stranded, circular varphiX replicative form I (RFI), or in single-stranded, circular varphiX viral DNA; it is inactive against all other species of DNA tested.

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References

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