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Clinical Trial
. 1974 Jun 29;2(5921):699-701.
doi: 10.1136/bmj.2.5921.699.

Propranolol in the treatment of migraine

T E Wideroe, T Vigander
Clinical Trial

Propranolol in the treatment of migraine

T E Wideroe et al. Br Med J. .

Abstract

Beta-blocking drugs that prevent cranial vasodilatation are potentially valuable in the prophylaxis of migraine. Forty-nine patients with either classic or common migraine were treated with propranolol 160 mg/day for an average of six months. The first 30 of the patients to respond well to this treatment then participated in a double-blind cross-over trial with a placebo and propranolol. The mean frequency of headache attacks was significantly reduced by propranolol. None of the patients expressed a preference for placebo. Propranolol seems to be an effective prophylactic for common and classic migraine but the antimigraine properties of the various beta-blocking agents probably differ.

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