Studies on the nephrotoxic activity of guinea-pig gamma-1 and gamma-2 antibodies
- PMID: 4605175
- PMCID: PMC1423083
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Studies on the nephrotoxic activity of guinea-pig gamma-1 and gamma-2 antibodies
Immunology.
1974 Feb.
Abstract
Nephrotoxic guinea-pig γ1 and γ2 immunoglobulins produce different patterns of proteinuria in the rat, the first acting like C-fixing rabbit antibody, while the second rather resembles duck nephrotoxic antibody. When both guinea-pig antibodies are combined in suitable proportions, a strong synergistic effect is observed and a great number of rats die within 24 hours showing the signs of a marked haemorrhagic glomerulonephritis.
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