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Comparative Study
. 1975 Jan 18;1(7899):142-3.
doi: 10.1016/s0140-6736(75)91433-6.

Probable identification of an HL-A second-locus antigen associated with a high risk of nasopharyngeal carcinoma

M J Simons, G B Wee, S H Chan, K Shanmugaratnam
Comparative Study

Probable identification of an HL-A second-locus antigen associated with a high risk of nasopharyngeal carcinoma

M J Simons et al. Lancet. .

Abstract

An HL-A antigen profile comprising an increased frequency of HL-A2 and undetectable second-locus antigen(s) in Chinese patients with nasopharyngeal carcinoma (N.P.C.) has been reported. To investigate whether the deficit of second-locus antigen(s) had a genetic basis, sera from parous women in Singapore were screened for anti HL-A activity corresponding to the second-locus "bland". A second-locus (Singapore-2) was identified which seems to be associated with a high risk of N.P.C.

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