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. 1974 Sep;119(3):1072-4.
doi: 10.1128/jb.119.3.1072-1074.1974.

Transformation of Salmonella typhimurium by plasmid deoxyribonucleic acid

E M Lederberg, S N Cohen

Transformation of Salmonella typhimurium by plasmid deoxyribonucleic acid

E M Lederberg et al. J Bacteriol. 1974 Sep.

Abstract

A modified transformation procedure that is effective for the introduction of plasmid deoxyribonucleic acid at high frequency into Salmonella typhimurium, as well as into Escherichia coli, is described. Transformed bacteria acquire a circular deoxyribonucleic acid species having the genetic and molecular characteristics of the transforming plasmid.

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