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. 1974 Sep 1;140(3):742-63.
doi: 10.1084/jem.140.3.742.

IgM-producing tumors in the BALB-c mouse: a model for B-cell maturation

J Andersson, J Buxbaum, R Citronbaum, S Douglas, L Forni, F Melchers, B Pernis, D Stott

IgM-producing tumors in the BALB-c mouse: a model for B-cell maturation

J Andersson et al. J Exp Med. .

Abstract

Five adjuvant induced BALB/c tumors producing IgM-McPc 1748, W 3469, TEPC 183, McPc 774, and Y 5781-were characterized morphologically by electron microscopy, analysis of the distribution of surface-bound and intracytoplasmic IgM using immunofluorescence, and by biochemical study of IgM synthesis, turnover, and secretion. The cells of different tumors appear to represent different stages in B-cell maturation when compared to normal, lipopolysaccharide-stimulated B cells. Thus, McPc 1748 tumor cells resemble 10-25-h stimulated normal B cells, 3469 cells resemble 20-35-h stimulated B cells, TEPC 183 cells resemble 45-65-h stimulated B cells, Y 5781 cells resemble 80-110-h stimulated B cells, and McPc 774 cells resemble 100-130-h stimulated B cells.

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