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. 1979 Mar;10(3):84-6.

Vitrectomy in experimental endophthalmitis: Part I-Fungal infection

K Huang, G A Peyman, J McGetrick
  • PMID: 460810

Vitrectomy in experimental endophthalmitis: Part I-Fungal infection

K Huang et al. Ophthalmic Surg. 1979 Mar.

Abstract

In studying the dose-related ocular toxicity of amphotericin B in vitrectomized eyes, up to 5 micrograms/0.1 ml concentration of amphotericin C was nontoxic to the ocular structure when injected in the anterior part of the vitreous cavity. Intravitreal injection of 2.5 micrograms of amphotericin B halted fungal endophthalmitis, which was experimentally induced in rabbit eyes, even after 16 days of infection. Combined treatment of vitrectomy and intravitreal injection of amphotericin B not only cured the fungal endophthalmitis but it also cleared the ocular media from opacities.

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