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. 1974 Sep;10(3):516-9.
doi: 10.1128/iai.10.3.516-519.1974.

Neutralizing antibody response of guinea pigs to lymphocytic choriomeningitis virus

J M Webster, B E Kirk

Neutralizing antibody response of guinea pigs to lymphocytic choriomeningitis virus

J M Webster et al. Infect Immun. 1974 Sep.

Abstract

A 24-h neutralization test that is based on fluorescent cell counting was used for the detection and quantitative determination of serum-neutralizing antibody against lymphocytic choriomeningitis virus. The earliest manifestation of serum-neutralizing antibody in guinea pigs was shown to occur within 1 week after inoculation with lymphocytic choriomeningitis virus. Within 11 weeks, serum-neutralizing antibody increased from 20- to 300-fold. Neutralizing end points of serum samples, obtained from 3 through 11 weeks, were enhanced as much as sevenfold by complement. Anti-guinea pig immunoglobulin G or anti-whole guinea pig serum potentiated the neutralizing activity of serum as much as 20- and 40-fold, respectively.

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