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. 1974 Dec 1;140(6):1579-87.
doi: 10.1084/jem.140.6.1579.

Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left-hand (K) half of H-2

A J Munro, M J Taussig, R Campbell, H Williams, Y Lawson

Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left-hand (K) half of H-2

A J Munro et al. J Exp Med. .

Abstract

Mouse thymus cells, educated to poly(tyrosyl,glutamyl)-polyDLalanyl--polylysyl [(T,G)-A--L], release an antigen-specific factor on brief culture in vitro. The factor cooperates with bone marrow cells in the antibody response to (T,G)-A--L in irradiated recipients. Its mol wt determined from Sephadex G100 chromatography is in the region of 50,000. The factor is removed by specific antigen-coated columns, but not by anti-immunoglobulin (anti-Fab, anti-micro, anti-Fv) adsorbents. The factor is removed by alloantisera directed against the H-2 haplotype of the strain in which it is produced. Moreover, only antisera with specificity for the K side of H-2 were successful in removing the factor activity.

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