doi: 10.1093/nar/6.6.2165.
The influence of terminal 3', 5' phosphates on conformations of dApdA
- PMID: 461185
- PMCID: PMC327843
- DOI: 10.1093/nar/6.6.2165
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The influence of terminal 3', 5' phosphates on conformations of dApdA
Nucleic Acids Res.
1979.
Abstract
Addition of 3' and 5' terminal phosphates to dApdA causes a decrease in conformational flexibility. pdApdAp has much fewer conformers with energies below 2.5 kcal./mole than dApdA. THE A, B and Watson-Crick (34) helices are the most preferred forms. Other important conformations are in the trans domain of psi. Thus, flexibility in psi as well as in omega and omega, and in the sugar pucker is indicated. The transformation from the B helix to the Watson-Crick helix follows a low energy path. This is significant since Watson-Crick conformations may be important for intercalation into nucleic acid polymers (40-42) above the dimer level. The B helix is preferred over the A form in these large DNA subunits.
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