Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979;6(6):2165-78.
doi: 10.1093/nar/6.6.2165.

The influence of terminal 3', 5' phosphates on conformations of dApdA

S Broyde, B Hingerty

The influence of terminal 3', 5' phosphates on conformations of dApdA

S Broyde et al. Nucleic Acids Res. 1979.

Abstract

Addition of 3' and 5' terminal phosphates to dApdA causes a decrease in conformational flexibility. pdApdAp has much fewer conformers with energies below 2.5 kcal./mole than dApdA. THE A, B and Watson-Crick (34) helices are the most preferred forms. Other important conformations are in the trans domain of psi. Thus, flexibility in psi as well as in omega and omega, and in the sugar pucker is indicated. The transformation from the B helix to the Watson-Crick helix follows a low energy path. This is significant since Watson-Crick conformations may be important for intercalation into nucleic acid polymers (40-42) above the dimer level. The B helix is preferred over the A form in these large DNA subunits.

PubMed Disclaimer

References

    1. Nucleic Acids Res. 1978 Nov;5(11):4399-416 - PubMed
    1. J Am Chem Soc. 1977 Oct 26;99(22):7333-48 - PubMed
    1. J Mol Biol. 1976 Sep 25;106(3):735-48 - PubMed
    1. Nucleic Acids Res. 1976 Aug;3(8):1973-84 - PubMed
    1. Nucleic Acids Res. 1978 Nov;5(11):4417-22 - PubMed

Publication types

Substances