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. 1974 Nov;71(11):4612-6.
doi: 10.1073/pnas.71.11.4612.

Mitochondrial genetics in Bakers' yeast: a molecular mechanism for recombinational polarity and suppressiveness

P S Perlman, C W Birky Jr

Mitochondrial genetics in Bakers' yeast: a molecular mechanism for recombinational polarity and suppressiveness

P S Perlman et al. Proc Natl Acad Sci U S A. 1974 Nov.

Abstract

Recombinational polarity and suppressiveness are two well-known but puzzling cytoplasmic genetic phenomena in bakers' yeast, Saccharomyces cerevisiae. Little progress has been made in characterizing the underlying molecular mechanisms of these phenomena. In this paper we describe a molecular model for recombinational polarity that is compatible with the available genetic evidence. The model stresses the role of small deletions and excision/repair processes in otherwise canonical recombinational events. According to the model, both phenomena require recombination and may share mechanistic elements.

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References

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