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Clinical Trial
. 1974;51(4):375-7.

Prophylactic activity of mefloquine hydrochloride (WR 142490) in drug-resistant malaria

K H Rieckmann, G M Trenholme, R L Williams, P E Carson, H Frischer, R E Desjardins
Clinical Trial

Prophylactic activity of mefloquine hydrochloride (WR 142490) in drug-resistant malaria

K H Rieckmann et al. Bull World Health Organ. 1974.

Abstract

In preliminary studies with mefloquine (WR 142 490) a single dose exerted prolonged suppressive activity against a drug-resistant strain of Plasmodium falciparum. Development of patent parasitaemia was prevented when nonimmune persons were exposed to infected mosquitos 2 weeks after medication, and it was delayed when exposure occurred 3 weeks after drug administration.

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References

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