Relaxant action of histamine on rabbit trachea: possible existence of third histamine receptor subtype
- PMID: 461948
Relaxant action of histamine on rabbit trachea: possible existence of third histamine receptor subtype
Abstract
The carbachol contracted rabbit trachea relaxes to isoproterenol, PGE1, E2, histamine and bradykinin. Histamine-induced relaxations were resistant to mepyramine (an H1-antagonist), burimamide, cimetidine, metiamide (H2-antagonists), propranolol (a beta-adrenoceptor blocker), indomethacin (a potent inhibitor of prostaglandin synthesis), trasylol (an inhibitor of kallikreins), aminophylline (a purinergic receptor blocker) and dibenzyline (a "D"-tryptamine receptor antagonist). The evidence achieved with these pharmacological agents appears to suggest that the chemical mediator responsible for the relaxant response to histamine is unlikely to be: catecholamines, prostaglandins, 5-HT, adenosine or ATP or kinins. The existence of H2-(iso or H3) histamine receptor subtype in rabbit trachea is postulated.
Similar articles
-
Further studies of dog tracheobronchial smooth muscle.Res Commun Chem Pathol Pharmacol. 1980 May;28(2):245-54. Res Commun Chem Pathol Pharmacol. 1980. PMID: 7394323
-
Histamine receptors of airway smooth muscle of ferret and rat.Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):55-65. Res Commun Chem Pathol Pharmacol. 1978. PMID: 28556
-
Atypical (relaxant) response to histamine in cat bronchus.Agents Actions. 1977 Jul;7(2):183-90. doi: 10.1007/BF01969970. Agents Actions. 1977. PMID: 19953
-
Bronchomotor tone and its modification by certain drugs.Postgrad Med J. 1976 Apr;52(606):190-6. doi: 10.1136/pgmj.52.606.190. Postgrad Med J. 1976. PMID: 5717 Free PMC article. Review.
-
Bronchoconstrictor drugs.Pharmacol Ther B. 1977;3(2):239-303. doi: 10.1016/0306-039x(77)90035-6. Pharmacol Ther B. 1977. PMID: 22879 Review. No abstract available.
Cited by
-
Effect of impromidine (SK&F 92676) on the isolated papillary muscle of the guinea-pig.Br J Pharmacol. 1981 Feb;72(2):197-9. doi: 10.1111/j.1476-5381.1981.tb09113.x. Br J Pharmacol. 1981. PMID: 6452187 Free PMC article.
-
Pharmacological study of bovine airways. Evidence for excitatory and inhibitory effects of histamine.Can J Comp Med. 1979 Oct;43(4):384-91. Can J Comp Med. 1979. PMID: 548161 Free PMC article.
-
On the mechanism of histamine-induced bronchodilation in conscious guinea-pigs.Agents Actions. 1984 Oct;15(3-4):285-9. doi: 10.1007/BF01972364. Agents Actions. 1984. PMID: 6395676
-
Antagonism of vasodepressor and gastric secretory responses to histamine by the H2-receptor antagonists, ranitidine and cimetidine, in the anaesthetized dog.Br J Pharmacol. 1981 Jan;72(1):55-60. doi: 10.1111/j.1476-5381.1981.tb09104.x. Br J Pharmacol. 1981. PMID: 6112035 Free PMC article.