4-aminobutyrate:2-oxoglutarate aminotransferase in blood platelets
- PMID: 462176
- DOI: 10.1126/science.462176
4-aminobutyrate:2-oxoglutarate aminotransferase in blood platelets
Abstract
Platelet lysates obtained from blood of humans, dogs, and rats catalyzed the transamination of 4-aminobutyrate with 2-oxoglutarate as cosubstrate. Human platelet 4-aminobutyrate:2-oxoglutarate aminotransferase (36.5 +/- 3.2 picomoles per minute per milligram of platelet protein) resembled the brain enzyme in kinetic properties and in response to cofactors and inhibitors.
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