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. 1972 May;22(5):711-21.

Interferon and haemopoietic colony inhibitor responses to poly I-poly C in rabbits and hamsters

T A McNeill, W A Fleming, D J McCance

Interferon and haemopoietic colony inhibitor responses to poly I-poly C in rabbits and hamsters

T A McNeill et al. Immunology. 1972 May.

Abstract

Intravenous or intraperitoneal inoculation of Poly I—Poly C into rabbits induced an inhibitor for rabbit bone marrow colony growth in the serum which associated with interferon after fractionation on Sephadex G-200. Inoculation of hamsters with Poly I—Poly C did not induce either inhibitor for hamster colonies or interferon. Other substances can cause colony inhibition besides interferon and these were detected in both normal rabbit and normal hamster serum. Colony inhibition shows some species specificity, but cross-inhibition of monkey and mouse colony growth was shown with rabbit inhibitor. It is suggested that the basic biological role of interferon may lie in the control of cellular differentiation.

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