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. 1972 May 1;135(5):1104-12.
doi: 10.1084/jem.135.5.1104.

Requirement of thymus (T) lymphocytes for resistance to listeriosis

F C Lane, E R Unanue

Requirement of thymus (T) lymphocytes for resistance to listeriosis

F C Lane et al. J Exp Med. .

Abstract

Spleen cells of mice infected with Listeria monocytogenes were adoptively transferred to normal mice. Such lymphocytes conferred resistance to a lethal challenge with Listeria. Hyperimmunization of the donor reduces the number of cells necessary to transfer effective immunity. Such spleen cells if treated with anti-theta serum do not transfer resistance to Listeria. Hence, thymus (T) lymphocytes are involved in the resistance to infection with the facultative intracellular bacteria L. monocytogenes.

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