Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1972 Apr 22;106(8):889-93.

Intrauterine infection and cord immunoglobulin M. I. Analysis of methods of assay and levels of immunoglobulin M in normal newborns

P B Dent, A Finkel, N Iturzaeta, M Gent, J Bienenstock

Intrauterine infection and cord immunoglobulin M. I. Analysis of methods of assay and levels of immunoglobulin M in normal newborns

P B Dent et al. Can Med Assoc J. .

Abstract

An analysis of methods of assay and levels of immunoglobulin M in the cord serum of 100 normal newborn infants is reported. The geometric mean level of cord IgM was found to be 9.8 mg.%. The 95th percentile value was 19.6 mg.%. IgM levels on day one were not significantly different from cord levels, while by day five a significant increase had occurred (geometric mean 13.6 mg.%). IgA was present in only 3/100 cord sera (in levels above 6.0 mg.%). Any increment of day five IgM over cord levels greater than threefold is thought to be abnormal and this parameter will be further evaluated as an index of neonatal sepsis. Use of locally produced reagents in the IgM assay was found to be more accurate and inexpensive than the commercially available reagents.

PubMed Disclaimer

References

    1. Immunochemistry. 1965 Sep;2(3):235-54 - PubMed
    1. N Engl J Med. 1966 Nov 3;275(18):971-7 - PubMed
    1. J Pediatr. 1967 Aug;71(2):181-91 - PubMed
    1. N Engl J Med. 1967 Aug 31;277(9):437-49 - PubMed
    1. N Engl J Med. 1968 Apr 11;278(15):809-14 - PubMed

LinkOut - more resources