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. 1975 Jan;114(1 Pt 1):161-4.

Antigenic relationship between the fourth component of human and guinea pig complement

S H Ohanian, T Borsos
  • PMID: 46239

Antigenic relationship between the fourth component of human and guinea pig complement

S H Ohanian et al. J Immunol. 1975 Jan.

Abstract

Antigenic similarity between cell-bound human and guinea pig C4 was detected with antisera specific for each of these molecules. No cross-reaction could be detected between C4 of normal guinea pig or human sera or after treatment of the sera with antigen-antibody C1 complexes. The cross-reactivity between cell-bound human and guinea pig C4 may reflect conformational changes in the C4 molecule as a result of binding of the cell surface.

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