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. 1972 Mar;10(3):453-61.

Myasthenia gravis. Antibodies to an acid-soluble antigen in striated muscle

J A Aarli

Myasthenia gravis. Antibodies to an acid-soluble antigen in striated muscle

J A Aarli. Clin Exp Immunol. 1972 Mar.

Abstract

Citric acid extracts were prepared from human skeletal and heart muscle. Antibodies of γG-class to components of this extract were demonstrated in twelve out of fifty-three sera from patients with myasthenia gravis. The antigen is poorly soluble in saline but is converted into a soluble form by diluted citric acid. Apparently, the antigen is also present in small amounts in saline extracts of thymus. No cross-reactivity with other organs was demonstrated.

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