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. 1972 Aug;111(2):586-92.
doi: 10.1128/jb.111.2.586-592.1972.

Mode of action of phleomycin on Bacillus subtilis

H Reiter, M Milewskiy, P Kelley

Mode of action of phleomycin on Bacillus subtilis

H Reiter et al. J Bacteriol. 1972 Aug.

Abstract

Phleomycin appears to act on the cell wall and membrane to induce the release of membrane-associated deoxyribonucleic acid (DNA) and the degradation of the DNA. Degradation occurs in a series of energy-requiring endonuclease and exonuclease reactions. These produce, first, single-strand breaks, then double-strand breaks, and finally almost complete solubilization of the cellular DNA. The in vivo inhibition of DNA synthesis by phleomycin is probably a secondary effect caused by the destruction of template DNA.

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References

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