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. 1975 Feb;15(2):407-15.
doi: 10.1128/JVI.15.2.407-415.1975.

Characterization of DNA polymerase and RNA associated with A-type particles from murine myeloma cells

D L Robertson, N L Baenziger, D C Dobbertin, R E Thach

Characterization of DNA polymerase and RNA associated with A-type particles from murine myeloma cells

D L Robertson et al. J Virol. 1975 Feb.

Abstract

The RNA-dependent DNA polymerase present in intracisternal A-type particles from mouse myeloma tumor cells has been studied. This polymerase can use either endogenous A particle RNA or an exogenous synthetic polynucleotide [poly (rA)] as a template. The DNA reaction product is small (4S-10S) and over 90% of it hybridizes to A particle RNA, whereas up to 50% of it hybridizes to murine sarcoma-leukemia virus RNAs. The RNA isolated from purified A particles is generally of low molecular weight (5S-15S) but contains small amount of 70S and 35S components. These results suggest that A-type particles may be related to C-type oncornaviruses.

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References

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