[Analysis of the RNA in different strains of the influenza A virus]

Abstract

The degree of affinity of influenza A/WSN/33 and A/Singapore/57 virus genomes was studied by the method of molecular hybridization which showed the presence in their genomes of 54--57% of analogous sequences. The electrophoretic analysis of RNA--RNA hybrids formed in hybridization of both homologous and heterologous virion and virus-induced RNAs of influenza viruses revealed significant differences in base sequences of the IV, V, and VIII fragments of influenza A/WSN/33 virus RNA and the corresponding fragments of influenza A/Singapore/57 virus RNA; the III and VII fragments of these strains have sites also differing in base sequences at the ends of molecules.