Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1973 Jan;52(1):198-204.
doi: 10.1172/JCI107165.

The occurrence of single-stranded DNA in the serum of patients with systemic lupus erythematosus and other diseases

D Koffler, V Agnello, R Winchester, H G Kunkel

The occurrence of single-stranded DNA in the serum of patients with systemic lupus erythematosus and other diseases

D Koffler et al. J Clin Invest. 1973 Jan.

Abstract

Single-stranded DNA (SDNA) occurs in high incidence and in greatest concentration in the sera of patients with systemic lupus erythematosus (SLE), where levels as high as 250 mug/ml were observed. SDNA appears to be an imunogen for anti-SDNA antibodies and forms complexes in vivo of both anti-SDNA-SDNA and anti-NDNA-SDNA types, which apparently play a role in the pathogenesis of the glomerulonephritis found in patients with SLE, SDNA is also found in high incidence but at lower levels in the sera of patients with rheumatoid arthritis. Lesser amounts of SDNA are found in several other diseases in which a low incidence of anti-SDNA antibodies is observed.

PubMed Disclaimer

References

    1. J Clin Invest. 1966 Nov;45(11):1732-40 - PubMed
    1. N Engl J Med. 1968 Mar 7;278(10):533-8 - PubMed
    1. Science. 1969 Dec 26;166(3913):1648-9 - PubMed
    1. Ann Intern Med. 1970 Jul;73(1):95-107 - PubMed
    1. J Clin Invest. 1970 Nov;49(11):2106-18 - PubMed

MeSH terms