The presence of donor-type immunoglobulins in anaemic mice of the W-series transplanted with allogeneic foetal liver cells

Abstract

W^vW^v mice have a genetically determined macrocytic anaemia. They may be cured by the injection of haemopoietic cells derived from foetal liver from haematologically normal mice, owing to the induction of bone marrow chimaerism.

Using foetal liver cells from mice that produce immunoglobulins of a different allotype from the anaemic recipients, it is shown that, after a period of time, all cured mice produce immunoglobulins of both the donor and recipient allotypes.