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. 1972;13(3):319-22.
doi: 10.1186/BF03547049.

The effect of ethionine feeding on the retention of a single per os dose of methyl mercury on rat

T J Pekkanen, K Salminen

The effect of ethionine feeding on the retention of a single per os dose of methyl mercury on rat

T J Pekkanen et al. Acta Vet Scand. 1972.

Abstract
in English, Swedish

Six adult female rats were daily fed a diet containing DL-ethionine during three weeks. One daily rat dose was 30 mg of ethionine. Six similar rats, the controls, were kept on the same diet without ethionine. On the 21st day of the experiment all rats were given one dose of 203Hg labeled methyl mercury by stomach tube. Each rat received 163 µg in terms of metallic mercury. Ninety hrs. after the mercury administration all rats were sacrificed and the mercury contents of the brains, livers, caudal femoral muscles, erythrocytes and blood plasma were determined. The mean plasma mercury content was significantly (P<0.01) greater in the ethionine fed rats when compared to the controls.

Sex fullvuxna hanråttor utfodrades dagligen under tre veckor med ett foder som innehöl DL-ethionin. Den dagliga dosen för en råtta var 30 mg ethionin. Sex likadana råttor, kontrollerna, fick samma foder utan ethionin. På den tjugoförsta dagen från experimentets början gavs alla råttor med en magsond 163 μg 203Hg märkt metylkvicksilver. Nittio timmar efter kvicksilvergivan avlivades råttorna och kvicksilverhalten i deras hjärnor, levrar, kaudala femorala muskler, röda blodkroppar och i blodplasma bestämdes. Plasmans genomsnittliga kvicksilverhalt var signifikant (P < 0,01) större i de med ethionin utfodrade råttorna jämfört med kontrollerna.

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References

    1. Bahr G F, Moberger G. Methylmercury-chloride as a specific reagent for protein-bound sulfhydryl groups. Electron stains II. Exp. Cell Res. 1954;6:506–518. - PubMed
    1. Hsu J M, Geller S. Increase in glutathione and glutathione reductase in livers of rats fed ethionine. Arch. Biochem. 1967;118:85–89.
    1. Hughes W L. Protein mercaptides. Cold Spring Harbor Symp. quant. Biol. 1949;14:79–84. doi: 10.1101/SQB.1950.014.01.011. - DOI - PubMed
    1. Hughes W L. A physicochemical rationale for the biological activity of mercury and its compounds. Ann. N.Y. Acad. Sci. 1957;65:454–460. doi: 10.1111/j.1749-6632.1956.tb36650.x. - DOI - PubMed
    1. Hughes, W. L., R. Straessle, H. Edelhoch & J. T. Edsall: Equilibrium, kinetics, and formation of intermediates in the reaction of human mercaptoalbumin with mercury compounds. 118th Meeting Amer. Chem. Soc. 1950, Div. Biol. Chem., 51c–52c.

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