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. 1972 Nov;6(5):699-702.
doi: 10.1128/iai.6.5.699-702.1972.

Stimulation of antibacterial vaccination in mice by polyadenylic acid: polyuridylic acid complex

G Renoux, M Renoux, R Branche

Stimulation of antibacterial vaccination in mice by polyadenylic acid: polyuridylic acid complex

G Renoux et al. Infect Immun. 1972 Nov.

Abstract

The effect of polyadenylic acid:polyuridylic acid complex (poly A:U) on immunization was investigated in mice vaccinated by killed Brucella melitensis cells suspended in incomplete adjuvant or in saline. Addition of 300 mug of poly A:U to vaccines rendered 3 x 10(8)B. melitensis cells in saline as immunogenic as 3 x 10(11) cells in oil adjuvant against a severe B. abortus challenge. In the mouse and Brucella system, poly A:U exerts an adjuvant effect on immunity but does not stimulate production of circulating antibodies that could be demonstrated at the time of autopsy.

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References

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