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. 1972 Nov;6(5):829-34.
doi: 10.1128/iai.6.5.829-834.1972.

A role for activated macrophages in resistance to infection with Toxoplasma

J S Remington, J L Krahenbuhl, J W Mendenhall

A role for activated macrophages in resistance to infection with Toxoplasma

J S Remington et al. Infect Immun. 1972 Nov.

Abstract

Activated macrophages from mice which were chronically infected with Toxoplasma gondii or Besnoitia jellisoni, or which had received Freund complete adjuvant, had an enhanced capacity to to kill intracellular Toxoplasma. Enhanced killing by activated macrophages was demonstrated by decreased incorporation of isotopically labeled uridine by intracellular Toxoplasma and by inhibition of plaque formation. The latter resulted from lack of proliferation of the intracellular Toxoplasma which is normally followed by destruction of the host cell (macrophage) and secondary invasion and destruction of fibroblast monolayers.

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References

    1. Proc Soc Exp Biol Med. 1957 Oct;96(1):7-10 - PubMed
    1. Int Arch Allergy Appl Immunol. 1967;32(2):149-63 - PubMed
    1. Proc Soc Exp Biol Med. 1970 Feb;133(2):623-6 - PubMed
    1. Infect Immun. 1970 Jun;1(6):600-3 - PubMed
    1. J Immunol. 1972 Feb;108(2):425-31 - PubMed

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