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. 1972 Dec 15;178(4066):1201-3.
doi: 10.1126/science.178.4066.1201.

Ragweed hay fever: genetic control and linkage to HL-A haplotypes

B B Levine, R H Stember, M Fotino

Ragweed hay fever: genetic control and linkage to HL-A haplotypes

B B Levine et al. Science. .

Abstract

Clinical ragweed pollenosis (hay fever) and IgE antibody production specific for antigen E (the major purified protein antigen from ragweed pollen extract) correlated closely with HL-A haplotypes in successive generations of seven families. HL-A associated IgE antibody responsiveness was antigen specific and extended also to IgE antibody production. These data indicate an immune response (Ir) gene specific for antigen E necessary but not sufficient for the development of hay fever. This appears to be the first documentation of an Ir gene in man.

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