The Clara cell: a comparative ultrastructural study in mammals
- PMID: 463790
- DOI: 10.1002/aja.1001550103
The Clara cell: a comparative ultrastructural study in mammals
Abstract
Clara cells in the terminal bronchoiles of mouse, rat, rabbit, calf and human were compared by light, transmission and scanning microscopy, and species-differences were clearly present. Mouse Clara cells were most numerous and mouse and rabbit Clara cells had large dense mitochondria. Rabbit and calf had glycogen in Clara cells and rat Clara cells had the most variability in secretory granules, some of which had a crystalline structure. Calf Clara cells had deeply indented nuclei. Human Clara cells had the most prominent nucleoli and lacked smooth endoplasmic reticulum, which was a prominent feature of most other species. No evidence of apical extrusion or apocrine secretion of Clara cell secretory granules was observed.
Similar articles
-
Comparative ultrastructure of Clara cells in neonatal and older cattle.J Morphol. 2000 May;244(2):143-51. doi: 10.1002/(SICI)1097-4687(200005)244:2<143::AID-JMOR5>3.0.CO;2-M. J Morphol. 2000. PMID: 10761052
-
Tracheobronchial epithelium of the sheep: II. Ultrastructural and morphometric analysis of the epithelial secretory cell types.Anat Rec. 1984 Aug;209(4):523-34. doi: 10.1002/ar.1092090412. Anat Rec. 1984. PMID: 6476418
-
Clara cell differentiation in the mouse: ultrastructural morphology and cytochemistry for surfactant protein A and Clara cell 10 kD protein.Microsc Res Tech. 1993 Dec 1;26(5):400-11. doi: 10.1002/jemt.1070260508. Microsc Res Tech. 1993. PMID: 8286786
-
The Clara cell.Eur J Respir Dis. 1982 May;63(3):202-20. Eur J Respir Dis. 1982. PMID: 7047186 Review.
-
Intestinal structure in relation to absorption.Biomembranes. 1974;4A(0):1-42. Biomembranes. 1974. PMID: 4609492 Review. No abstract available.
Cited by
-
Ontogeny and Biology of Human Small Airway Epithelial Club Cells.Am J Respir Crit Care Med. 2018 Dec 1;198(11):1375-1388. doi: 10.1164/rccm.201710-2107OC. Am J Respir Crit Care Med. 2018. PMID: 29874100 Free PMC article.
-
Cancer in relation to occupational exposure to trichloroethylene.Occup Environ Med. 1996 Jan;53(1):1-5. doi: 10.1136/oem.53.1.1. Occup Environ Med. 1996. PMID: 8563851 Free PMC article. Review. No abstract available.
-
Effects of ultrafine particles-induced oxidative stress on Clara cells in allergic lung inflammation.Part Fibre Toxicol. 2010 Apr 26;7:11. doi: 10.1186/1743-8977-7-11. Part Fibre Toxicol. 2010. PMID: 20420656 Free PMC article.
-
Anatomy of Clara cell secretion: surface changes observed by scanning electron microscopy.J Anat. 1993 Jun;182 ( Pt 3)(Pt 3):377-88. J Anat. 1993. PMID: 8226293 Free PMC article.
-
Pulmonary toxicity and carcinogenicity of trichloroethylene: species differences and modes of action.Environ Health Perspect. 2000 May;108 Suppl 2(Suppl 2):261-4. doi: 10.1289/ehp.00108s2261. Environ Health Perspect. 2000. PMID: 10807556 Free PMC article. Review.